Kidney Disease

Authors: John Dirks, Shuchi Anand, Bernadette Thomas, Giuseppe Remuzzi, Miguel Riella, Meguid El Nahas, Saraladevi Naicker

Introduction:

Deterioration in kidney function, whether acute or chronic, can lead to substantial morbidity and mortality. Acute kidney injury (AKI) is a powerful indicator for in-hospital mortality; those who survive face increased length and cost of hospitalization. Some individuals with chronic kidney disease (CKD) develop progressive renal dysfunction and require costly therapy with dialysis and/or transplant. Even more often, individuals with CKD face high risks for cardiovascular events, anemia, and fractures.   

This chapter reviews current data on the epidemiology and trends in the etiology of AKI, CKD, and end-stage renal disease (ESRD), with a focus on low- and middle-income countries (LMICs). We also review management of these conditions, highlighting several interventions—treatment for AKI, screening for CKD, and modality choice for ESRD—with available data on cost or cost-effectiveness.   Deterioration in kidney function, whether acute or chronic, can lead to substantial morbidity and mortality. Acute kidney injury (AKI) is a powerful indicator for in-hospital mortality; those who survive face increased length and cost of hospitalization. Some individuals with chronic kidney disease (CKD) develop progressive renal dysfunction and require costly therapy with dialysis and/or transplant. Even more often, individuals with CKD face high risks for cardiovascular events, anemia, and fractures.   

Contact:

To submit comments or queries about this chapter, please send an email to corresponding author Dr. John Dirks at john.dirks@gairdner.org

 

 

AttachmentSize
540.89 KB