Peripheral Artery Disease

Authors: Uchechukwu Sampson, Gerald Fowkes, Nadraj Naidoo, Michael Criqui


This chapter discusses the global epidemiology of peripheral artery disease (PAD) based on recent evidence that provides (1) updated comparisons of age- and gender-specific prevalence between high-income countries (HICs) and low- and middle-income countries (LMICs); (2) risk factors for PAD in HICs and LMICs; (3) robust estimates of PAD deaths and the number of people living with PAD regionally and globally; and (4) insights into the implications of current PAD epidemiology for potential cost-effective approaches to prevention and treatment in LMICs. PAD represents a global problem, evidenced by increased associated disability and mortality and a striking relative increase in the burden of disease in LMICs. The rising disease burden among women and increased involvement of young adults indicate that PAD is no longer limited to men or elderly persons. Governments, nongovernmental organizations, and private sectors in LMICs need to address the social and economic impacts and evaluate the best strategies for optimal treatment and prevention.



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